Statistical models to study subtoxic concentrations for some standard mutagens in three colon cancer cell lines

Xavier Bardina*, Laura Fernández+, Elisabet Pineiro+, Jordi Surrallés+, Antonia Velázquez+

*Departament de Matemàtiques, +Departament de Genètica
Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain.

 

Abstract

The aim of this work is to propose models to study the toxic effect of different concentrations of some
standard mutagens in different colon cancer cell lines. We find estimates and, by means of an inverse
regression problem, confidence intervals for the subtoxic concentration, that is the concentration that
reduces by thirty percent the number of colonies obtained in the absence of mutagen.
 
Keywords: Inverse regression problem, subtoxic concentration, confidence interval.

Published in:  SORT 30(2) 193-204 (2006)